abstract:BACKGROUND:Chronic kidney disease (CKD) is associated with an increased risk of the progression of coronary artery disease (CAD). However, there are few data on the relationship between CAD severity and the duration of CKD. This study assessed the predictive value of the duration of kidney dysfunction in CKD patients w...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1880936
更新日期:2021-12-01 00:00:00
abstract::Effective treatments for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Dexamethasone has been shown to confer survival benefits to certain groups of hospitalized patients, but whether glucocorticoids such as dexamethasone and methylpredn...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1885998
更新日期:2021-12-01 00:00:00
abstract::In order to isolated and identified the bacterial strains from wheat rhizosphere and evaluated the effect of different concentration of bacterial fermentation broth on the wild oats weed growth. This experiment carried out the separation and purification of dominant bacterial strains from the wheat rhizosphere soil, a...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1877413
更新日期:2021-12-01 00:00:00
abstract::Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes in the expression of related cytokines are closely related to the path...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1873978
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Recently published data suggest that showing patients operated on for adolescent idiopathic scoliosis or kyphosis their preoperative and postoperative photographs may enhance their satisfaction and self-image as measured by Scoliosis Research Society Health-Related Quality of Life Questionnaire (SRS-22) scor...
journal_title:International journal of spine surgerypub_type: 杂志文章
doi:10.14444/7155
更新日期:2021-12-01 00:00:00
abstract::The Adipoq-Cre transgenic mouse is widely used in the development of adipocyte-specific genetic manipulations for the study of obesity and type 2 diabetes. In the process of developing a new mouse model utilizing the adipocyte selective Adipoq-Cre transgenic mouse, strong genetic linkage between a gene of interest, Ad...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1880083
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Growth differentiation factor 15(GDF15) is a distant member of the superfamily of the transforming growth factor beta (TGF-β). It has been established that increased GDF15 levels are associated with an increased risk of cardiovascular disease. However, the detail effect of GDF15 on cardiovascular system in p...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1880938
更新日期:2021-12-01 00:00:00
abstract::Increased visceral adipose tissue (VAT) is associated with metabolic dysfunction, while subcutaneous adipose tissue (SAT) is considered protective. The mechanisms underlying these differences are not fully elucidated. This study aimed to investigate molecular differences in VAT and SAT of male Wistar rats fed a cafete...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1886697
更新日期:2021-12-01 00:00:00
abstract::Coronavirus disease-2019 (COVID-19) is a recent world pandemic disease that is caused by a newly discovered strain of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2). Patients with comorbidities are most vulnerable to this disease. Therefore, cancer patients are reported to be more susceptible to COV...
journal_title:Current research in microbial sciencespub_type: 杂志文章
doi:10.1016/j.crmicr.2021.100022
更新日期:2021-12-01 00:00:00
abstract::Successful shared decision making (SDM) in clinical practice requires that future clinicians learn to appreciate the value of patient participation as early as they can in their medical training. Narratives, such as patient testimonials, have been successfully used to support patients' decision-making process. Previou...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1886642
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:To the best of our knowledge, the effectiveness and safety of lactulose in comparison to sennosides, for the prevention of peritoneal dialysis (PD)-related peritonitis, has never been tested in a randomized study. METHODS:We conducted an open-label, randomized, active-controlled trial in a PD-center in Nort...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1889023
更新日期:2021-12-01 00:00:00
abstract::The COVID-19 pandemic has substantially strained health systems across the globe. In particular, documented disruptions to voluntary family planning and reproductive health care due to competing health priorities, service disruptions, stockouts, and lockdowns are significantly impacting reproductive, maternal, newborn...
journal_title:Sexual and reproductive health matterspub_type: 杂志文章
doi:10.1080/26410397.2021.1881210
更新日期:2021-12-01 00:00:00
abstract::Purpose: Healthy lifestyle interventions after breast cancer treatment have generally been studied in terms of weight-loss outcomes, which leaves a gap in our understanding of the phenomenological experience of such programs. Our knowledge of how or why women recovering from breast cancer engage or do not engage in th...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2020.1864903
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:There are few effective therapies for coronavirus disease 2019 (COVID-19) upon the outbreak of the pandemic. To compare the effectiveness of a novel genetically engineered recombinant super-compound interferon (rSIFN-co) with traditional interferon-alpha added to baseline antiviral agents (lopinavir-ritonavi...
journal_title:Annals of medicinepub_type: 信件,多中心研究,随机对照试验
doi:10.1080/07853890.2021.1890329
更新日期:2021-12-01 00:00:00
abstract::To enhance the efficacy of radiation therapy, functionalised core-shell nanoparticles (CS NPs) are used as a radiosensitizer. These NPs can act as a therapeutic agent and carrier for other therapeutic agents. In this study, the first poly-acrylic acid modified silver-coated titanium dioxide NPs were fabricated to eval...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1889574
更新日期:2021-12-01 00:00:00
abstract::IMP-45, a variant of IMP-9, is one of the dominant metallo-β-lactamases (MBLs) in clinical carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates in China. The aim of this study was to investigate the distribution and mechanism of dissemination of blaIMP-45. MBL genes were detected by PCR in 173 non-duplicate CRP...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1894903
更新日期:2021-12-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs), as one common type of non-coding RNAs, play a critical role in the tumorigenesis and development of hepatocellular carcinoma (HCC). In the current study, we aimed to assess the correlation between lncRNAs expression levels and prognosis of HCC patients. A lncRNA-based signature was also...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1878763
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key ...
journal_title:Redox report : communications in free radical researchpub_type: 杂志文章
doi:10.1080/13510002.2021.1891808
更新日期:2021-12-01 00:00:00
abstract::The paper aims to assess the association between Hepatitis B Virus infection and colorectal liver metastasis by conducting a meta-analysis. The relevant studies were searched until 24 July 2020, Studies that assessed the correlation between HBV infection and CRLM were recruited. A random effects model was applied to c...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1890871
更新日期:2021-12-01 00:00:00
abstract::Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1892458
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Insulin-like growth factor-binding protein (IGFBP) 2 plays an important role in the regulation of cell adhesion, migration, growth, and apoptosis. This study aimed to investigate the clinical significance of serum IGFBP2 as a biomarker for disease activity and severity in hemolytic uremic syndrome (HUS) indu...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1885445
更新日期:2021-12-01 00:00:00
abstract::This study aimed to assess the effectiveness and safety of intravesical instillation treatment of Kangfuxin liquid (KFL) combined with thrombin and epidermal growth factor (EGF) for radiation-induced hemorrhagic cystitis (HC) in patients with cervical cancer. A total of 34 patients with radiation-induced HC of grade 2...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1882141
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. METHODS:We conducted a p...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1892759
更新日期:2021-12-01 00:00:00
abstract::Owing to the recent outbreak of Coronavirus Disease of 2019 (COVID-19), it is urgent to develop effective and safe drugs to treat the present pandemic and prevent other viral infections that might come in the future. Proteins from our own innate immune system can serve as ideal sources of novel drug candidates thanks ...
journal_title:Virulencepub_type: 杂志文章,评审
doi:10.1080/21505594.2021.1871823
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:: Congenital dysfibrinogenemia (CD) is a coagulation disorder caused by mutations in the fibrinogen genes, which result in abnormal fibrinogen function. However, the precise pathogenesis underlying it remains unclear. METHODS:: In this study, we identified a novel heterozygous mutation in an asymptomatic pa...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1893977
更新日期:2021-12-01 00:00:00
abstract::ABSTRACTSeveral subtypes of avian influenza (AI) viruses have caused human infections in recent years; however, there is a severe knowledge gap regarding the capacity of wild bird viruses to infect mammals. To assess the risk of mammalian infection by AI viruses from their natural reservoirs, a panel of isolates from ...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1899769
更新日期:2021-12-01 00:00:00
abstract::Diabetes associated injury healing and other tissue irregularities are viewed as a significant concern. The purpose of the study is to design the wound regeneration activity of Ficus carica extract (FFE) loaded amphiphilic polymeric scaffold of poly(xylitol-g-adipate-co-glutamide) (PXAG)-polyhydroxybutyrate (PHB) for ...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1890610
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Naoxintong (NXT), a prescribed traditional Chinese medicine, widely used in cerebrovascular and cardiovascular diseases, could be effective in diabetic wounds. OBJECTIVE:This study evaluates the wound healing activity of NXT by employing an excisional wound splinting model. MATERIALS AND METHODS:NXT was disso...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1877735
更新日期:2021-12-01 00:00:00
abstract::Transarterial chemoembolization is a standard treatment for intermediate-stage hepatocellular carcinoma (HCC). This study evaluated the anti-tumor effect of the semi-interpenetrating network (IPN) hydrogel as a novel embolic material for trans-portal vein chemoembolization (TPVE) in vivo. A nude mice orthotopic HCC mo...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1895908
更新日期:2021-12-01 00:00:00
abstract::COVID-19 vaccines emerging from different platforms differ in efficacy, duration of protection, and side effects. To maximize the benefits of vaccination, we explored the utility of employing a heterologous prime-boost strategy in which different combinations of the four types of leading COVID-19 vaccine candidates th...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1902245
更新日期:2021-12-01 00:00:00
abstract::Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus disease 2019 (COVID-19). We enrolled 4 patients hospitalized with critical COVI...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1902754
更新日期:2021-12-01 00:00:00
abstract::SARS-CoV-2 is the causative agent of COVID-19 and responsible for the current global pandemic. We and others have previously demonstrated that cats are susceptible to SARS-CoV-2 infection and can efficiently transmit the virus to naïve cats. Here, we address whether cats previously exposed to SARS-CoV-2 can be re-infe...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1902753
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:General practitioners (GPs) encounter women suffering from premenstrual symptoms. Often women with premenstrual problems experience little understanding from GPs. Views of GPs will influence their approach to these women and their care. Insight into these views is lacking but could help in designing educatio...
journal_title:The European journal of general practicepub_type: 杂志文章
doi:10.1080/13814788.2021.1889505
更新日期:2021-12-01 00:00:00
abstract::Candida parapsilosis is a leading cause of invasive mycoses and the major cause of nosocomial fungaemia amongst low and very low birth weight neonates. However, the molecular and physiological characteristics of this fungus remain understudied. To advance our knowledge about the pathobiology of this pathogen, we sough...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1893008
更新日期:2021-12-01 00:00:00
abstract::Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and negatively affect public health. The development of new drugs would be an effective means of solving this problem. Modifications base...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1900163
更新日期:2021-12-01 00:00:00
abstract::Triamcinolone acetonide (TA) is widely indicated in the treatment of several ocular disorders, but the free drug suspension limits its clinical benefits and commercial compositions cause adverse ocular effects. In this study, TA was formulated in poly(d,l-lactide-co-glycolide) (PLGA)-chitosan (PLC) nanoparticles (NPs)...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1895184
更新日期:2021-12-01 00:00:00
abstract::Purpose: This study aims to construct a theoretical framework that explains how users with comorbidity of substance use and mental illness/neuropsychiatric disorders portray user participation in social work encounters.Methods: To construct this framework a constructivist grounded theory approach was used with semi-st...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1901468
更新日期:2021-12-01 00:00:00
abstract::Multidrug resistance (MDR) and lack of targeting specificity are the main reasons why traditional drug therapies fail and produce toxic side effects in cancer chemotherapy. In order to increase targeting specificity and maximize therapeutic efficacy, new intelligent drug delivery systems are needed. In this study, we ...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1905751
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Pomelo peel oil (PPO) [Citrus maxima (Burm.) Merr. (Rutaceae)] is reported to possess antioxidant and antimelanogenic activities. OBJECTIVE:To investigate the effect of PPO [Citrus maxima (Burm.) Merr. cv. Shatian Yu] on tumour necrosis factor-α (TNF-α)-induced necroptosis in cerebral ischaemia-reperfusion inj...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1903046
更新日期:2021-12-01 00:00:00
abstract:AIMS:The objective was to evaluate the clinical characteristics, management and two-year outcomes of patients with newly diagnosed non-valvular atrial fibrillation at risk for stroke in Nordic countries. METHODS:We examined the baseline characteristics, antithrombotic treatment, and two-year clinical outcomes of patie...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1893897
更新日期:2021-12-01 00:00:00